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Svaret;
The short answer is no, if the Pogo Connect pens are set up correctly, they shouldn't interfere with each other. At trade shows, we have had 4 iPads running at the same time with a Pogo Connect pen for each. To make it easy, we generally would set up the pen's connection to an iPad one at a time. What can get a bit tricky, is if the pen disconnects from the app. When reconnecting, sometimes the different Pogo Connect pens in close proximity may show up in the app's settings, and you'll want to be sure you are connecting the app to the correct pen.
Of course, the more iPads that are involved, the more involved the set up may be.